Red rip cells are crucial to expect oxygen from the lungs to cells and to take away carbon dioxide . They are form in the crimson bone marrow , but new research implies that this might not be the full photo . novel evidence suggests that a small fraction of blood cells can shape in the bowel too .
The inquiry , published in the journalCell Stem Cell , comes from the discovery that patient role who received an intestinal transplant also received stem cells that can mature into full stock cells . This leads to episodes of rake chimerism in the recipient , where different blood types Centennial State - subsist for a while . This surprising fact could have an authoritative benefit .
enteric transplantation is the only long - term option for affected role whose intestines have bomb , such as people who have Crohn ’s disease . regrettably , this type of transplant has in high spirits rejection rate and life - peril complications due to the immunosuppression medications need . Those drug assist to stop the immune system of the organ transplant liquidator from destroying the transplanted organ .
But the presence of these hematopoietic stem cells seems to change things a bit . The matured cells from the intestine seem to be tolerant of the recipient ’s own tissue . And the resistant organization of the recipient seems to be educated by the donor cells in being tolerant of the transplanted electronic organ .
" We are clearly demo that there ’s immunological cross - public lecture between the two sets of lineage cell that protects the graft from the patient ’s immune system and protects the patient role from the transplant , " older author Dr Megan Sykes , manager of the Columbia Center for Translational Immunology , said in astatement . " It ’s potential that patients with a high level of donor cells may not require as much immunosuppression as they are currently get and reduce immunosuppression could improve outcomes . "
The study canvass 21 patients who receive an intestinal transplant . If these finding are confirmed , the habit of hematopoietic stem cells could be a Modern weapon in our medical arsenal . This approach could improve the chances of many transplant receivers .
" That could improve the life story of transplant patients dramatically , " Sykes excuse . " Our ultimate goal is to get immune tolerance , which would allow us to remove immunosuppression altogether and have the transplant treated as self by the affected role . That ’s really the Holy Grail . "
The squad design to enquire if boosting hematopoietic shank cells during enteral transplants moderate to more immune tolerance .
