It’s the end of an era forThe Ellen DeGeneres Show.

Beginning Sept. 13, hostEllen DeGenereswill kick off the 19th and final season of her namesake talk show.

In PEOPLE’s exclusive first look at the upcoming season, the clip provides a glimpse at many highlights featured on DeGeneres' series over the years.

At the end of it all, there’s still “one thankful host” who has been with viewers throughout the nearly two decades-long journey. “You’ve changed my life,” DeGeneres, 63, says.

Ellen

The Ellen DeGeneres Show’s Farewell Season

DeGeneres announced in May that she will beending her long-running talk showin 2022. She toldThe Hollywood Reporterthat the shakeup, which comes afterallegations of a toxic work environmenton the series' set, is due to her needing “something new to challenge” her.

“I was going to stop after season 16. That was going to be my last season, and they wanted to sign for four more years and I said I’d sign maybe for one,” she continued. “They were saying there was no way to sign for one. ‘We can’t do that with the affiliates and the stations need more of a commitment.'”

“So, we [settled] on three more years, and I knew that would be my last. That’s been the plan all along,” she added.

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The Ellen DeGeneres Show’s Farewell Season

DeGeneres further addressed the decision during a discussion withOprah Winfrey. “I feel like it’s the right thing to do, but I’m charged,” she told Winfrey, 67, on her show. “It’s a weird thing to announce that I’m stopping,”

She additionally explained that “there’s just different things as a creative person that I feel like I need to do” going forward.

TheEllen DeGeneresShowreturns for its final season on Sept. 13.

source: people.com